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Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability
Polyploid cancer cells exhibit chromosomal instability (CIN), which is associated with tumorigenesis and therapy resistance. The mechanisms that induce polyploidy and how these mechanisms contribute to CIN are not fully understood. Here we evaluate CIN in human cells that become polyploid through an...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042578/ https://www.ncbi.nlm.nih.gov/pubmed/27489338 http://dx.doi.org/10.1091/mbc.E16-03-0159 |