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Characterization of Amyloid Cores in Prion Domains

Amyloids consist of repetitions of a specific polypeptide chain in a regular cross-β-sheet conformation. Amyloid propensity is largely determined by the protein sequence, the aggregation process being nucleated by specific and short segments. Prions are special amyloids that become self-perpetuating...

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Detalles Bibliográficos
Autores principales: Sant’Anna, Ricardo, Fernández, Maria Rosario, Batlle, Cristina, Navarro, Susanna, de Groot, Natalia S., Serpell, Louise, Ventura, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043269/
https://www.ncbi.nlm.nih.gov/pubmed/27686217
http://dx.doi.org/10.1038/srep34274