Single-cell analysis reveals IGF-1 potentiation of inhibition of the TGF-β/Smad pathway of fibrosis in human keratocytes in vitro

Corneal wound healing is often affected by TGF-β–mediated fibrosis and scar formation. Guided fibrosis with IGF-1 and antifibrotic substances might maintain corneal transparency. Primary human corneal keratocytes under serum-free conditions were used as a model of corneal stromal wounding, with mark...

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Detalles Bibliográficos
Autores principales: Sarenac, Tomislav, Trapecar, Martin, Gradisnik, Lidija, Rupnik, Marjan Slak, Pahor, Dusica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043377/
https://www.ncbi.nlm.nih.gov/pubmed/27687492
http://dx.doi.org/10.1038/srep34373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043377/
https://www.ncbi.nlm.nih.gov/pubmed/27687492
http://dx.doi.org/10.1038/srep34373

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