Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy

Neurodegenerative disorders referred to as tauopathies, which includes Alzheimer’s disease (AD), are characterized by insoluble deposits of the tau protein within neuron cell bodies and dendritic processes in the brain. Tau is normally associated with microtubules (MTs) in axons, where it provides M...

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Detalles Bibliográficos
Autores principales: Makani, Vishruti, Zhang, Bin, Han, Heeoon, Yao, Yuemang, Lassalas, Pierrik, Lou, Kevin, Paterson, Ian, Lee, Virginia M. Y., Trojanowski, John Q., Ballatore, Carlo, Smith, Amos B., Brunden, Kurt R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043530/
https://www.ncbi.nlm.nih.gov/pubmed/27687527
http://dx.doi.org/10.1186/s40478-016-0378-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043530/
https://www.ncbi.nlm.nih.gov/pubmed/27687527
http://dx.doi.org/10.1186/s40478-016-0378-4

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