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Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy
Neurodegenerative disorders referred to as tauopathies, which includes Alzheimer’s disease (AD), are characterized by insoluble deposits of the tau protein within neuron cell bodies and dendritic processes in the brain. Tau is normally associated with microtubules (MTs) in axons, where it provides M...
Autores principales: | Makani, Vishruti, Zhang, Bin, Han, Heeoon, Yao, Yuemang, Lassalas, Pierrik, Lou, Kevin, Paterson, Ian, Lee, Virginia M. Y., Trojanowski, John Q., Ballatore, Carlo, Smith, Amos B., Brunden, Kurt R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043530/ https://www.ncbi.nlm.nih.gov/pubmed/27687527 http://dx.doi.org/10.1186/s40478-016-0378-4 |
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