Exploring the active site of the Streptococcus pneumoniae topoisomerase IV–DNA cleavage complex with novel 7,8-bridged fluoroquinolones

As part of a programme of synthesizing and investigating the biological properties of new fluoroquinolone antibacterials and their targeting of topoisomerase IV from Streptococcus pneumoniae, we have solved the X-ray structure of the complexes of two new 7,8-bridged fluoroquinolones (with restricted...

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Detalles Bibliográficos
Autores principales: Laponogov, Ivan, Pan, Xiao-Su, Veselkov, Dennis A., Cirz, Ryan T., Wagman, Allan, Moser, Heinz E., Fisher, L. Mark, Sanderson, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043579/
https://www.ncbi.nlm.nih.gov/pubmed/27655731
http://dx.doi.org/10.1098/rsob.160157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043579/
https://www.ncbi.nlm.nih.gov/pubmed/27655731
http://dx.doi.org/10.1098/rsob.160157

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