Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice

In order to treat progressive paralysis in ALS patients, it is critical to develop a mouse that closely models human ALS in both pathology and also in the timing of these events. We have recently generated new TDP-43 bigenic mice (called rNLS8) with doxycycline (Dox)-suppressible expression of human...

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Detalles Bibliográficos
Autores principales: Spiller, Krista J., Restrepo, Clark R., Khan, Tahiyana, Stieber, Anna M., Kwong, Linda K., Trojanowski, John Q., Lee, Virginia M.-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043606/
https://www.ncbi.nlm.nih.gov/pubmed/27687289
http://dx.doi.org/10.1186/s40478-016-0377-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043606/
https://www.ncbi.nlm.nih.gov/pubmed/27687289
http://dx.doi.org/10.1186/s40478-016-0377-5

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