Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance

BACKGROUND: Our previous study demonstrated that metabolic inflammation exacerbates dopaminergic neuronal degeneration in type 2 diabetes mice. Metformin, a typical oral hypoglycemic agent for diabetes, has been regarded as an activator of AMP-activated protein kinase and a regulator of systemic ene...

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Detalles Bibliográficos
Autores principales: Lu, Ming, Su, Cunjin, Qiao, Chen, Bian, Yaqi, Ding, Jianhua, Hu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043649/
https://www.ncbi.nlm.nih.gov/pubmed/27207919
http://dx.doi.org/10.1093/ijnp/pyw047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043649/
https://www.ncbi.nlm.nih.gov/pubmed/27207919
http://dx.doi.org/10.1093/ijnp/pyw047

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