Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism

The hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes (PHDs) regulate the stability of HIF protein by post-translational hydroxylation of two conserved prolyl residues in its α subunit in an oxygen-dependent manner. Trans-4-prolyl hydroxylation of HIFα under normal oxygen (O(2)) avail...

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Detalles Bibliográficos
Autores principales: Yang, Ming, Su, Huizhong, Soga, Tomoyoshi, Kranc, Kamil R, Pollard, Patrick J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045062/
https://www.ncbi.nlm.nih.gov/pubmed/27774472
http://dx.doi.org/10.2147/HP.S47968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045062/
https://www.ncbi.nlm.nih.gov/pubmed/27774472
http://dx.doi.org/10.2147/HP.S47968

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