Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

Reversible infantile liver failure (RILF) is a unique heritable liver disease characterized by acute liver failure followed by spontaneous recovery at an early stage of life. Genetic mutations in MTU1 have been identified in RILF patients. MTU1 is a mitochondrial enzyme that catalyzes the 2-thiolati...

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Detalles Bibliográficos
Autores principales: Wu, Yong, Wei, Fan-Yan, Kawarada, Layla, Suzuki, Takeo, Araki, Kimi, Komohara, Yoshihiro, Fujimura, Atsushi, Kaitsuka, Taku, Takeya, Motohiro, Oike, Yuichi, Suzuki, Tsutomu, Tomizawa, Kazuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045200/
https://www.ncbi.nlm.nih.gov/pubmed/27689697
http://dx.doi.org/10.1371/journal.pgen.1006355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045200/
https://www.ncbi.nlm.nih.gov/pubmed/27689697
http://dx.doi.org/10.1371/journal.pgen.1006355

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