Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons

Cell-fate reprograming is at the heart of development, yet very little is known about the molecular mechanisms promoting or inhibiting reprograming in intact organisms. In the C. elegans germline, reprograming germ cells into somatic cells requires chromatin perturbation. Here, we describe that such...

Descripción completa

Detalles Bibliográficos
Autores principales: Seelk, Stefanie, Adrian-Kalchhauser, Irene, Hargitai, Balázs, Hajduskova, Martina, Gutnik, Silvia, Tursun, Baris, Ciosk, Rafal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045294/
https://www.ncbi.nlm.nih.gov/pubmed/27602485
http://dx.doi.org/10.7554/eLife.15477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045294/
https://www.ncbi.nlm.nih.gov/pubmed/27602485
http://dx.doi.org/10.7554/eLife.15477

Ejemplares similares