Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging

The aim of this study was to clarify the synergistic effects of dual inhibition of the PI3K/mTOR and MAPK pathways in ovarian mucinous carcinoma (OMC) cells, using fluorescence resonance energy transfer (FRET) imaging. We exposed 6 OMC cell lines to a PI3K/mTOR inhibitor (voxtalisib, SAR245409) and/...

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Detalles Bibliográficos
Autores principales: Inaba, Kanako, Oda, Katsutoshi, Aoki, Kazuhiro, Sone, Kenbun, Ikeda, Yuji, Miyasaka, Aki, Kashiyama, Tomoko, Fukuda, Tomohiko, Makii, Chinami, Arimoto, Takahide, Wada-Hiraike, Osamu, Kawana, Kei, Yano, Tetsu, Osuga, Yutaka, Fujii, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045418/
https://www.ncbi.nlm.nih.gov/pubmed/27102436
http://dx.doi.org/10.18632/oncotarget.8807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045418/
https://www.ncbi.nlm.nih.gov/pubmed/27102436
http://dx.doi.org/10.18632/oncotarget.8807

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