DNA replication stress: a source of APOBEC3B expression in breast cancer

APOBEC cytidine deaminases have been implicated as major contributors to the mutation burden in many cancers on the basis of their mutational signature. A new experimental study sheds light on the inciting factors, linking APOBEC3B expression to oncogene- and drug-induced replication stress. ELECTRO...

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Detalles Bibliográficos
Autores principales: Cescon, David W., Haibe-Kains, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045630/
https://www.ncbi.nlm.nih.gov/pubmed/27716362
http://dx.doi.org/10.1186/s13059-016-1069-y
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author Cescon, David W.
Haibe-Kains, Benjamin
author_facet Cescon, David W.
Haibe-Kains, Benjamin
author_sort Cescon, David W.
collection PubMed
description APOBEC cytidine deaminases have been implicated as major contributors to the mutation burden in many cancers on the basis of their mutational signature. A new experimental study sheds light on the inciting factors, linking APOBEC3B expression to oncogene- and drug-induced replication stress. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13059-016-1069-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-50456302016-10-05 DNA replication stress: a source of APOBEC3B expression in breast cancer Cescon, David W. Haibe-Kains, Benjamin Genome Biol Research Highlight APOBEC cytidine deaminases have been implicated as major contributors to the mutation burden in many cancers on the basis of their mutational signature. A new experimental study sheds light on the inciting factors, linking APOBEC3B expression to oncogene- and drug-induced replication stress. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13059-016-1069-y) contains supplementary material, which is available to authorized users. BioMed Central 2016-09-30 /pmc/articles/PMC5045630/ /pubmed/27716362 http://dx.doi.org/10.1186/s13059-016-1069-y Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Cescon, David W.
Haibe-Kains, Benjamin
DNA replication stress: a source of APOBEC3B expression in breast cancer
title DNA replication stress: a source of APOBEC3B expression in breast cancer
title_full DNA replication stress: a source of APOBEC3B expression in breast cancer
title_fullStr DNA replication stress: a source of APOBEC3B expression in breast cancer
title_full_unstemmed DNA replication stress: a source of APOBEC3B expression in breast cancer
title_short DNA replication stress: a source of APOBEC3B expression in breast cancer
title_sort dna replication stress: a source of apobec3b expression in breast cancer
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045630/
https://www.ncbi.nlm.nih.gov/pubmed/27716362
http://dx.doi.org/10.1186/s13059-016-1069-y
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