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P53 regulates disruption of neuronal development in the adult hippocampus after irradiation

Inhibition of hippocampal neurogenesis is implicated in neurocognitive dysfunction after cranial irradiation for brain tumors. How irradiation results in impaired neuronal development remains poorly understood. The Trp53 (p53) gene is known to regulate cellular DNA damage response after irradiation....

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Detalles Bibliográficos
Autores principales: Li, Y-Q, Cheng, ZW-C, Liu, SK-W, Aubert, I, Wong, C S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045962/
https://www.ncbi.nlm.nih.gov/pubmed/27752364
http://dx.doi.org/10.1038/cddiscovery.2016.72