Improved affinity at the cost of decreased specificity: a recurring theme in PDZ-peptide interactions

The E6 protein from human papillomavirus (HPV) plays an important role during productive infection and is a potential drug target. We have previously designed a high affinity bivalent protein binder for the E6 protein, a fusion between a helix from the E6 associated protein and PDZØ9, an engineered...

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Detalles Bibliográficos
Autores principales: Karlsson, O. Andreas, Sundell, Gustav N., Andersson, Eva, Ivarsson, Ylva, Jemth, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046105/
https://www.ncbi.nlm.nih.gov/pubmed/27694853
http://dx.doi.org/10.1038/srep34269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046105/
https://www.ncbi.nlm.nih.gov/pubmed/27694853
http://dx.doi.org/10.1038/srep34269

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