Discovery of Isoquinolinoquinazolinones as a Novel Class of Potent PPARγ Antagonists with Anti-adipogenic Effects

Conformational change in helix 12 can alter ligand-induced PPARγ activity; based on this reason, isoquinolinoquinazolinones, structural homologs of berberine, were designed and synthesized as PPARγ antagonists. Computational docking and mutational study indicated that isoquinolinoquinazolinones form...

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Detalles Bibliográficos
Autores principales: Jin, Yifeng, Han, Younho, Khadka, Daulat Bikram, Zhao, Chao, Lee, Kwang Youl, Cho, Won-Jea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046141/
https://www.ncbi.nlm.nih.gov/pubmed/27695006
http://dx.doi.org/10.1038/srep34661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046141/
https://www.ncbi.nlm.nih.gov/pubmed/27695006
http://dx.doi.org/10.1038/srep34661

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