Cargando…

Discovery of Isoquinolinoquinazolinones as a Novel Class of Potent PPARγ Antagonists with Anti-adipogenic Effects

Conformational change in helix 12 can alter ligand-induced PPARγ activity; based on this reason, isoquinolinoquinazolinones, structural homologs of berberine, were designed and synthesized as PPARγ antagonists. Computational docking and mutational study indicated that isoquinolinoquinazolinones form...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Yifeng, Han, Younho, Khadka, Daulat Bikram, Zhao, Chao, Lee, Kwang Youl, Cho, Won-Jea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046141/ https://www.ncbi.nlm.nih.gov/pubmed/27695006 http://dx.doi.org/10.1038/srep34661

Ejemplares similares

Osterix represses adipogenesis by negatively regulating PPARγ transcriptional activity
por: Han, Younho, et al.
Publicado: (2016)

Identification of an irreversible PPARγ antagonist with potent anticancer activity
por: Peng, Youyi, et al.
Publicado: (2020)

Honokiol: A non-adipogenic PPARγ agonist from nature()
por: Atanasov, Atanas G., et al.
Publicado: (2013)

The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists
por: Tsukahara, Tamotsu
Publicado: (2012)

Identification of Bexarotene as a PPARγ Antagonist with HDX
por: Marciano, David P., et al.
Publicado: (2015)

PPARγ agonist through the terminal differentiation phase is essential for adipogenic differentiation of fetal ovine preadipocytes
por: Pu, Yong, et al.
Publicado: (2017)

Amidation-Modified Apelin-13 Regulates PPARγ and Perilipin to Inhibit Adipogenic Differentiation and Promote Lipolysis
por: Wang, Sha, et al.
Publicado: (2021)

Adipogenic differentiation was inhibited by downregulation of PPARγ signaling pathway in aging tendon stem/progenitor cells
por: Lai, Fan, et al.
Publicado: (2021)

Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome
por: Bryant, Claire, et al.
Publicado: (2022)

Discovery of Potent Glucokinase and PPARγ Dual-Target Agonists through an Innovative Scheme for Regioselective Modification of Silybin
por: Zhang, Zhipeng, et al.
Publicado: (2022)

Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069
por: Orsi, Douglas L., et al.
Publicado: (2022)

Promoter–enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase
por: LeBlanc, Scott E., et al.
Publicado: (2016)

Correction to “Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069”
por: Orsi, Douglas L., et al.
Publicado: (2022)

Ginsenoside Rc Promotes Anti-Adipogenic Activity on 3T3-L1 Adipocytes by Down-Regulating C/EBPα and PPARγ
por: Yang, Ji-Won, et al.
Publicado: (2015)

Synergistic Antiproliferative Effects of Combined γ-Tocotrienol and PPARγ Antagonist Treatment Are Mediated through PPARγ-Independent Mechanisms in Breast Cancer Cells
por: Malaviya, Abhita, et al.
Publicado: (2014)

The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ
por: Watanabe, Masashi, et al.
Publicado: (2015)

CpG Methylation across the adipogenic PPARγ gene and its relationship with birthweight and child BMI at 9 years
por: Volberg, Vitaly, et al.
Publicado: (2017)

Celecoxib induces adipogenic differentiation of hemangioma-derived mesenchymal stem cells through the PPAR-γ pathway in vitro and in vivo
por: Wang, Yuan, et al.
Publicado: (2022)

Structure-Based Virtual Screening and Discovery of New PPARδ/γ Dual Agonist and PPARδ and γ Agonists
por: Maltarollo, Vinicius G., et al.
Publicado: (2015)

Over-expression of PPAR-γ2 gene enhances the adipogenic differentiation of hemangioma-derived mesenchymal stem cells in vitro and in vivo
por: Yuan, Si-Ming, et al.
Publicado: (2017)

Transient expression of inactive RB in mesenchymal stem cells impairs their adipogenic potential and is associated with hypermethylation of the PPARγ2 promoter
por: Baryshev, Mikhail, et al.
Publicado: (2020)

Molecular docking analysis of PPARγ antagonists for obesity associated diabetes management
por: Ahmad, Aftab, et al.
Publicado: (2023)

Artemisia princeps Inhibits Adipogenic Differentiation of 3T3-L1 Pre-Adipocytes via Downregulation of PPARγ and MAPK Pathways
por: Oh, Jung Hwan, et al.
Publicado: (2019)

PPARγ Agonist and Angiotensin II Receptor Antagonist Ameliorate Renal Tubulointerstitial Fibrosis
por: Han, Jee-Young, et al.
Publicado: (2010)

Involvement of PPARγ in the Anticonvulsant Activity of EP-80317, a Ghrelin Receptor Antagonist
por: Lucchi, Chiara, et al.
Publicado: (2017)

Acetylated-PPARγ expression is regulated by different P53 genotypes associated with the adipogenic differentiation of polyploid giant cancer cells with daughter cells
por: Zhang, Kexin, et al.
Publicado: (2023)

Discovery and Identification of Pyrazolopyramidine Analogs as Novel Potent Androgen Receptor Antagonists
por: Wang, Lingyan, et al.
Publicado: (2018)

Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening
por: Diao, Yanyan, et al.
Publicado: (2018)

Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins
por: Lamb, Kelsey N., et al.
Publicado: (2021)

Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists
por: Valentini, Alice, et al.
Publicado: (2023)

Protopanaxatriol, a novel PPARγ antagonist from Panax ginseng, alleviates steatosis in mice
por: Zhang, Yu, et al.
Publicado: (2014)

PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix
por: Frkic, Rebecca L., et al.
Publicado: (2018)

FRI026 PPARγ Antagonists Induce Aromatase Transcription In Human Adipose Tissue Cells
por: Ardenkjær-Skinnerup, Jacob, et al.
Publicado: (2023)

Induction of MYCN-amplified neuroblastoma differentiation through NMYC suppression using PPAR-γ antagonist
por: Nakao-Ise, Yukako, et al.
Publicado: (2023)

PPARγ in Neuroblastoma
por: Peri, Alessandro, et al.
Publicado: (2008)

Novel derivatives of eugenol as potent anti-inflammatory agents via PPARγ agonism: rational design, synthesis, analysis, PPARγ protein binding assay and computational studies
por: Anjum, Noor Fathima, et al.
Publicado: (2022)

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
por: Kulkarni, Ajit A., et al.
Publicado: (2012)

Phenyllactic Acid from Lactobacillus plantarum Promotes Adipogenic Activity in 3T3-L1 Adipocyte via Up-Regulation of PPAR-γ2
por: Ilavenil, Soundharrajan, et al.
Publicado: (2015)

Sargassum miyabei Yendo Brown Algae Exert Anti-Oxidative and Anti-AdipogenicEffects on 3T3-L1 Adipocytes by Downregulating PPARγ
por: Kim, Dong Se, et al.
Publicado: (2020)

Genistin: A Novel Potent Anti-Adipogenic and Anti-Lipogenic Agent
por: Choi, Yae Rim, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_s31v8vam6o7sfdmh4jsmoc7d34