Cargando…
Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway
Indatraline is an antidepressive agent and a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). In this study, we report that indatraline induces autophagy via the suppression of mTOR/S6 kinase signaling. Autophagy i...
Autores principales: | Cho, Yoon Sun, Yen, Chih-na, Shim, Joong Sup, Kang, Dong Hoon, Kang, Sang Won, Liu, Jun O., Kwon, Ho Jeong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046148/ https://www.ncbi.nlm.nih.gov/pubmed/27694974 http://dx.doi.org/10.1038/srep34655 |
Ejemplares similares
-
Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein
por: Hwang, Hui-Yun, et al.
Publicado: (2020) -
Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase
por: Walton, Jeffrey G A, et al.
Publicado: (2011) -
Indatraline: Synthesis and Effect on the Motor Activity of Wistar Rats
por: Kameyama, Márcia, et al.
Publicado: (2011) -
Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition
por: Bray, Kevin, et al.
Publicado: (2012) -
mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)