Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer

BACKGROUND: There is increasing evidence that oncogenic Wnt signaling directs metabolic reprogramming of cancer cells to favor aerobic glycolysis or Warburg metabolism. In colon cancer, this reprogramming is due to direct regulation of pyruvate dehydrogenase kinase 1 (PDK1) gene transcription. Addit...

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Detalles Bibliográficos
Autores principales: Sprowl-Tanio, Stephanie, Habowski, Amber N., Pate, Kira T., McQuade, Miriam M., Wang, Kehui, Edwards, Robert A., Grun, Felix, Lyou, Yung, Waterman, Marian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046889/
https://www.ncbi.nlm.nih.gov/pubmed/27729975
http://dx.doi.org/10.1186/s40170-016-0159-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046889/
https://www.ncbi.nlm.nih.gov/pubmed/27729975
http://dx.doi.org/10.1186/s40170-016-0159-3

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