Cargando…

Molecular stripping, targets and decoys as modulators of oscillations in the NF-κB/IκBα/DNA genetic network

Eukaryotic transcription factors in the NF-κB family are central components of an extensive genetic network that activates cellular responses to inflammation and to a host of other external stressors. This network consists of feedback loops that involve the inhibitor IκBα, numerous downstream functi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Zhipeng, Potoyan, Davit A., Wolynes, Peter G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2016
Materias:	Life Sciences–Physics interface
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046959/ https://www.ncbi.nlm.nih.gov/pubmed/27683001 http://dx.doi.org/10.1098/rsif.2016.0606

Ejemplares similares

Modeling the therapeutic efficacy of NFκB synthetic decoy oligodeoxynucleotides (ODNs)
por: Wang, Zhipeng, et al.
Publicado: (2018)

DDRGK1 Regulates NF-κB Activity by Modulating IκBα Stability
por: Xi, Peng, et al.
Publicado: (2013)

Atypical IκB proteins – nuclear modulators of NF-κB signaling
por: Schuster, Marc, et al.
Publicado: (2013)

Role of Monoubiquitylation on the Control of IκBα Degradation and NF-κB Activity
por: Da Silva-Ferrada, Elisa, et al.
Publicado: (2011)

Beyond NF-κB activation: nuclear functions of IκB kinase α
por: Huang, Wei-Chien, et al.
Publicado: (2013)

NF-κB Decoy Oligodeoxynucleotide-Coated Balloon Catheter for Arteriovenous Fistula in Hemodialysis
por: Fukasawa, Mizuya, et al.
Publicado: (2018)

IκBα beyond the NF-kB dogma
por: Mulero, Maria Carmen, et al.
Publicado: (2013)

Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice
por: Shukla, Sanjeev, et al.
Publicado: (2015)

NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer
por: Espinosa, Lluís, et al.
Publicado: (2021)

Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway
por: Jie, Zuliang, et al.
Publicado: (2021)

HSPA13 facilitates NF-κB–mediated transcription and attenuates cell death responses in TNFα signaling
por: Gao, Chun, et al.
Publicado: (2021)

STAT3/NF-κB decoy oligodeoxynucleotides inhibit atherosclerosis through regulation of the STAT/NF-κB signaling pathway in a mouse model of atherosclerosis
por: An, Hyun-Jin, et al.
Publicado: (2023)

Overexpression of IκB⍺ modulates NF-κB activation of inflammatory target gene expression
por: Downton, Polly, et al.
Publicado: (2023)

Polymorphisms of NFκB1 and IκBα and Their Synergistic Effect on Nasopharyngeal Carcinoma Susceptibility
por: Liu, Yehua, et al.
Publicado: (2015)

Histone deacetylase 4 inhibits NF-κB activation by facilitating IκBα sumoylation
por: Yang, Qi, et al.
Publicado: (2021)

TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα
por: Ji, Jianxiong, et al.
Publicado: (2020)

Neuroprotective potential of fisetin in an experimental model of spinal cord injury: via modulation of NF-κB/IκBα pathway
por: Cui, Jing, et al.
Publicado: (2021)

Influence of pentylenetetrazol and NF-κB decoy oligodeoxynucleotides on p38 expression in neuron-like cells
por: YANG, JIA-JUN, et al.
Publicado: (2014)

Aptamer-Mediated Codelivery of Doxorubicin and NF-κB Decoy Enhances Chemosensitivity of Pancreatic Tumor Cells
por: Porciani, David, et al.
Publicado: (2015)

Computer vision reveals hidden variables underlying NF-κB activation in single cells
por: Patel, Parthiv, et al.
Publicado: (2021)

Spatiotemporal NF-κB dynamics encodes the position, amplitude, and duration of local immune inputs
por: Son, Minjun, et al.
Publicado: (2022)

Regulation of IκBα expression involves both NF-κB and the MAP kinase signaling pathways
por: Zhang, Ning, et al.
Publicado: (2005)

Regulation of NF-κB inhibitor IκBα and viral replication by a KSHV microRNA
por: Lei, Xiufen, et al.
Publicado: (2010)

Essential Role of Nuclear Factor (NF)-κB–Inducing Kinase and Inhibitor of κb (Iκb) Kinase α in Nf-κb Activation through Lymphotoxin β Receptor, but Not through Tumor Necrosis Factor Receptor I
por: Matsushima, Akemi, et al.
Publicado: (2001)

Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-κB Through the Modulation of IκBα Sumoylation
por: Xie, Hongyi, et al.
Publicado: (2020)

Evaluation of the osteogenic effect of apigenin on human mesenchymal stem cells by inhibiting inflammation through modulation of NF-κB/IκBα
por: Asadi, Azita, et al.
Publicado: (2022)

Functional Redundancy of the Nuclear Factor κB Inhibitors IκBα and IκBβ
por: Cheng, Janet D., et al.
Publicado: (1998)

IκBɛ provides negative feedback to control NF-κB oscillations, signaling dynamics, and inflammatory gene expression
por: Kearns, Jeffrey D., et al.
Publicado: (2006)

Disulfide-Mediated Stabilization of the IκB Kinase Binding Domain of NF-κB Essential Modulator (NEMO)
por: Zhou, Li, et al.
Publicado: (2014)

Inhibitory effect of ribbon-type NF-κB decoy oligodeoxynucleotides on osteoclast induction and activity in vitro and in vivo
por: Kunugiza, Yasuo, et al.
Publicado: (2006)

Heterologous SUMO-2/3-Ubiquitin Chains Optimize IκBα Degradation and NF-κB Activity
por: Aillet, Fabienne, et al.
Publicado: (2012)

Inhibitory effects of evodiamine on zymosan-induced inflammation: inactivation of NF-κB by inhibiting IκBα phosphorylation
por: Fan, X, et al.
Publicado: (2014)

The Circadian Nobiletin-ROR Axis Suppresses Adipogenic Differentiation and IκBα/NF-κB Signaling in Adipocytes
por: Kim, Eunju, et al.
Publicado: (2023)

Role of NF-κB during Mycobacterium tuberculosis Infection
por: Poladian, Nicole, et al.
Publicado: (2023)

Oscillation dynamics underlie functional switching of NF-κB for B-cell activation
por: Inoue, Kentaro, et al.
Publicado: (2016)

Single TNFα trimers mediating NF-κB activation: stochastic robustness of NF-κB signaling
por: Lipniacki, Tomasz, et al.
Publicado: (2007)

Porcine arterivirus activates the NF-κB pathway through IκB degradation
por: Lee, Sang-Myeong, et al.
Publicado: (2005)

The microdissected gene expression landscape of nasopharyngeal cancer reveals vulnerabilities in FGF and noncanonical NF-κB signaling
por: Tay, Joshua K., et al.
Publicado: (2022)

Regulation of NF-κB Oscillation by Nuclear Transport: Mechanisms Determining the Persistency and Frequency of Oscillation
por: Ohshima, Daisuke, et al.
Publicado: (2015)

High-Throughput Analysis of NF-κB Dynamics in Single Cells Reveals Basal Nuclear Localization of NF-κB and Spontaneous Activation of Oscillations
por: Zambrano, Samuel, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5g7nl3j29t27q0p9m731pkkvih