Synthesis of triazole-linked morpholino oligonucleotides via Cu(I) catalysed cycloaddition

Triazole-linked morpholino ((TL)MO) oligonucleic acids were synthesised using the Cu(I) catalysed (3 + 2) azide–alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the (TL)MO modificat...

Descripción completa

Detalles Bibliográficos
Autores principales: Palframan, Matthew J., Alharthy, Rima D., Powalowska, Paulina K., Hayes, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047124/
https://www.ncbi.nlm.nih.gov/pubmed/26905296
http://dx.doi.org/10.1039/c6ob00007j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047124/
https://www.ncbi.nlm.nih.gov/pubmed/26905296
http://dx.doi.org/10.1039/c6ob00007j

Ejemplares similares