The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS

Full length TrkC (TrkC-FL) is a receptor tyrosine kinase whose mRNA can be spliced to a truncated TrkC.T1 isoform lacking the kinase domain. Neurotrophin-3 (NT-3) activates TrkC-FL to maintain motor neuron health and function and TrkC.T1 to produce neurotoxic TNF-α; hence resulting in opposing pathw...

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Detalles Bibliográficos
Autores principales: Brahimi, Fouad, Maira, Mario, Barcelona, Pablo F., Galan, Alba, Aboulkassim, Tahar, Teske, Katrina, Rogers, Mary-Louise, Bertram, Lisa, Wang, Jing, Yousefi, Masoud, Rush, Robert, Fabian, Marc, Cashman, Neil, Saragovi, H. Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047590/
https://www.ncbi.nlm.nih.gov/pubmed/27695040
http://dx.doi.org/10.1371/journal.pone.0162307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047590/
https://www.ncbi.nlm.nih.gov/pubmed/27695040
http://dx.doi.org/10.1371/journal.pone.0162307

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