Synthesis, Pharmacological Profile and Docking Studies of New Sulfonamides Designed as Phosphodiesterase-4 Inhibitors

Prior investigations showed that increased levels of cyclic AMP down-regulate lung inflammatory changes, stimulating the interest in phosphodiesterase (PDE)4 as therapeutic target. Here, we described the synthesis, pharmacological profile and docking properties of a novel sulfonamide series (5 and 6...

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Detalles Bibliográficos
Autores principales: Nunes, Isabelle Karine da Costa, de Souza, Everton Tenório, Cardozo, Suzana Vanessa S., Carvalho, Vinicius de Frias, Romeiro, Nelilma Correia, Silva, Patrícia Machado Rodrigues e, Martins, Marco Aurélio, Barreiro, Eliezer J., Lima, Lídia Moreira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047629/
https://www.ncbi.nlm.nih.gov/pubmed/27695125
http://dx.doi.org/10.1371/journal.pone.0162895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047629/
https://www.ncbi.nlm.nih.gov/pubmed/27695125
http://dx.doi.org/10.1371/journal.pone.0162895

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