The membrane trafficking and functionality of the K(+)-Cl(−) co-transporter KCC2 is regulated by TGF-β2

Functional activation of the neuronal K(+)-Cl(−) co-transporter KCC2 (also known as SLC12A5) is a prerequisite for shifting GABA(A) responses from depolarizing to hyperpolarizing during development. Here, we introduce transforming growth factor β2 (TGF-β2) as a new regulator of KCC2 membrane traffic...

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Detalles Bibliográficos
Autores principales: Roussa, Eleni, Speer, Jan Manuel, Chudotvorova, Ilona, Khakipoor, Shokoufeh, Smirnov, Sergei, Rivera, Claudio, Krieglstein, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047681/
https://www.ncbi.nlm.nih.gov/pubmed/27505893
http://dx.doi.org/10.1242/jcs.189860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047681/
https://www.ncbi.nlm.nih.gov/pubmed/27505893
http://dx.doi.org/10.1242/jcs.189860

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