Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets

A hallmark of all primary and metastatic tumours is their high rate of glucose uptake and glycolysis. A consequence of the glycolytic phenotype is the accumulation of metabolic acid; hence, tumour cells experience considerable intracellular acid stress. To compensate, tumour cells upregulate acid pu...

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Detalles Bibliográficos
Autores principales: Shin, John J., Aftab, Qurratulain, Austin, Pamela, McQueen, Jennifer A., Poon, Tak, Li, Shu Chen, Young, Barry P., Roskelley, Calvin D., Loewen, Christopher J. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047693/
https://www.ncbi.nlm.nih.gov/pubmed/27519690
http://dx.doi.org/10.1242/dmm.023374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047693/
https://www.ncbi.nlm.nih.gov/pubmed/27519690
http://dx.doi.org/10.1242/dmm.023374

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