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A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP-43(A315T) mutant C57BL6/J mice

Transgenic transactivation response DNA-binding protein 43 (TDP-43) mice expressing the A315T mutation under control of the murine prion promoter progressively develop motor function deficits and are considered a new model for the study of amyotrophic lateral sclerosis (ALS); however, premature sudd...

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Detalles Bibliográficos
Autores principales: Coughlan, Karen S., Halang, Luise, Woods, Ina, Prehn, Jochen H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047697/
https://www.ncbi.nlm.nih.gov/pubmed/27491077
http://dx.doi.org/10.1242/dmm.024786