The Oncoprotein BRD4-NUT Generates Aberrant Histone Modification Patterns

Defects in chromatin proteins frequently manifest in diseases. A striking case of a chromatin-centric disease is NUT-midline carcinoma (NMC), which is characterized by expression of NUT as a fusion partner most frequently with BRD4. ChIP-sequencing studies from NMC patients revealed that BRD4-NUT (B...

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Detalles Bibliográficos
Autores principales: Zee, Barry M., Dibona, Amy B., Alekseyenko, Artyom A., French, Christopher A., Kuroda, Mitzi I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047744/
https://www.ncbi.nlm.nih.gov/pubmed/27698495
http://dx.doi.org/10.1371/journal.pone.0163820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047744/
https://www.ncbi.nlm.nih.gov/pubmed/27698495
http://dx.doi.org/10.1371/journal.pone.0163820

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