Scaffold Hopping Toward Agomelatine: Novel 3, 4-Dihydroisoquinoline Compounds as Potential Antidepressant Agents

A scaffold-hopping strategy toward Agomelatine based on in silico screening and knowledge analysis was employed to design novel antidepressant agents. A series of 3, 4-dihydroisoquinoline compounds were selected for chemical synthesis and biological assessment. Three compounds (6a-1, 6a-2, 6a-9) dem...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Yang, Ang, Wei, Long, Haiyue, Chang, Ying, Li, Zicheng, Zhou, Liangxue, Yang, Tao, Deng, Yong, Luo, Youfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048153/
https://www.ncbi.nlm.nih.gov/pubmed/27698414
http://dx.doi.org/10.1038/srep34711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048153/
https://www.ncbi.nlm.nih.gov/pubmed/27698414
http://dx.doi.org/10.1038/srep34711

Ejemplares similares