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Scaffold Hopping Toward Agomelatine: Novel 3, 4-Dihydroisoquinoline Compounds as Potential Antidepressant Agents

A scaffold-hopping strategy toward Agomelatine based on in silico screening and knowledge analysis was employed to design novel antidepressant agents. A series of 3, 4-dihydroisoquinoline compounds were selected for chemical synthesis and biological assessment. Three compounds (6a-1, 6a-2, 6a-9) dem...

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Detalles Bibliográficos
Autores principales:	Yang, Yang, Ang, Wei, Long, Haiyue, Chang, Ying, Li, Zicheng, Zhou, Liangxue, Yang, Tao, Deng, Yong, Luo, Youfu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048153/ https://www.ncbi.nlm.nih.gov/pubmed/27698414 http://dx.doi.org/10.1038/srep34711

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