Cargando…

Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites

Central to the pathogenesis of malaria is the proliferation of Plasmodium falciparum parasites within human erythrocytes. Parasites invade erythrocytes via a coordinated sequence of receptor-ligand interactions between the parasite and host cell. One key ligand, Apical Membrane Antigen 1 (AMA1), is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prinz, Boris, Harvey, Katherine L., Wilcke, Louisa, Ruch, Ulrike, Engelberg, Klemens, Biller, Laura, Lucet, Isabelle, Erkelenz, Steffen, Heincke, Dorothee, Spielmann, Tobias, Doerig, Christian, Kunick, Conrad, Crabb, Brendan S., Gilson, Paul R., Gilberger, Tim W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048298/ https://www.ncbi.nlm.nih.gov/pubmed/27698395 http://dx.doi.org/10.1038/srep34479

Ejemplares similares

Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum
por: Engelberg, Klemens, et al.
Publicado: (2013)

Pellicle formation in the malaria parasite
por: Kono, Maya, et al.
Publicado: (2016)

Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite
por: Leykauf, Kerstin, et al.
Publicado: (2010)

4-Arylthieno[2,3-b]pyridine-2-carboxamides Are a New Class of Antiplasmodial Agents
por: Schweda, Sandra I., et al.
Publicado: (2020)

Structure–activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines
por: Masch, Andreas, et al.
Publicado: (2019)

Functional inactivation of Plasmodium falciparum glycogen synthase kinase GSK3 modulates erythrocyte invasion and blocks gametocyte maturation
por: Alder, Arne, et al.
Publicado: (2022)

Functional Analysis of the Leading Malaria Vaccine Candidate AMA-1 Reveals an Essential Role for the Cytoplasmic Domain in the Invasion Process
por: Treeck, Moritz, et al.
Publicado: (2009)

Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes
por: Tham, Wai-Hong, et al.
Publicado: (2015)

Synthesis and Antiplasmodial Activity of Bisindolylcyclobutenediones
por: Lande, Duc Hoàng, et al.
Publicado: (2021)

The Dynamic Roles of the Inner Membrane Complex in the Multiple Stages of the Malaria Parasite
por: Ferreira, Josie Liane, et al.
Publicado: (2021)

Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites
por: Yap, Alan, et al.
Publicado: (2014)

Defining species-specific and conserved interactions of apical membrane protein 1 during erythrocyte invasion in malaria to inform multi-species vaccines
por: Drew, Damien R., et al.
Publicado: (2023)

Do apicomplexan parasite-encoded proteins act as both ligands and receptors during host cell invasion?
por: Gilson, Paul R, et al.
Publicado: (2009)

Hierarchical Censored Bayesian Analysis of Visual Field Progression
por: Montesano, Giovanni, et al.
Publicado: (2021)

Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon
por: Crabb, Brendan S, et al.
Publicado: (2011)

Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity
por: Ruch, Travis R., et al.
Publicado: (2017)

A novel inhibitor rescues cerebellar defects in a zebrafish model of Down syndrome–associated kinase Dyrk1A overexpression
por: Buchberger, Astrid, et al.
Publicado: (2021)

Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export
por: Charnaud, Sarah C., et al.
Publicado: (2018)

Novel 2-Phenoxyanilide Congeners Derived from a Hit Structure of the TCAMS: Synthesis and Evaluation of Their in Vitro Activity against Plasmodium falciparum
por: Weidner, Thomas, et al.
Publicado: (2016)

The ZIP Code of Vesicle Trafficking in Apicomplexa: SEC1/Munc18 and SNARE Proteins
por: Bisio, Hugo, et al.
Publicado: (2020)

Synthesis and Properties of a Selective Inhibitor of Homeodomain–Interacting Protein Kinase 2 (HIPK2)
por: Cozza, Giorgio, et al.
Publicado: (2014)

PfATP4 inhibitors in the Medicines for Malaria Venture Malaria Box and Pathogen Box block the schizont-to-ring transition by inhibiting egress rather than invasion
por: Barnes, Claudia B. G., et al.
Publicado: (2022)

Plasmodium falciparum Transfected with Ultra Bright NanoLuc Luciferase Offers High Sensitivity Detection for the Screening of Growth and Cellular Trafficking Inhibitors
por: Azevedo, Mauro F., et al.
Publicado: (2014)

The Modular Circuitry of Apicomplexan Cell Division Plasticity
por: Gubbels, Marc-Jan, et al.
Publicado: (2021)

Proteomic characterization of the Toxoplasma gondii cytokinesis machinery portrays an expanded hierarchy of its assembly and function
por: Engelberg, Klemens, et al.
Publicado: (2022)

The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites
por: Looker, Oliver, et al.
Publicado: (2022)

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design
por: Meine, Rosanna, et al.
Publicado: (2018)

Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B
por: Papenfuss, Marco, et al.
Publicado: (2022)

Resección apical
por: Rodríguez Barradas, Jesús
Publicado: (1994)

APIC vision
por: Dickey, Linda
Publicado: (2022)

Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum
por: Dickerman, Benjamin K., et al.
Publicado: (2016)

Comparison of Endodontic Biomaterials as Apical Barriers in Simulated Open Apices
por: Adel, Mamak, et al.
Publicado: (2012)

Microbiota in the apical root canal system of tooth with apical periodontitis
por: Qian, Wenhao, et al.
Publicado: (2019)

Apical but not sub-apical hyphal compartments are self-sustaining in growth
por: Tegelaar, Martin, et al.
Publicado: (2020)

Effectiveness of MTA apical plug in dens evaginatus with open apices
por: Van Pham, Khoa, et al.
Publicado: (2021)

Apical Ischemia Is a Universal Feature of Apical Hypertrophic Cardiomyopathy
por: Hughes, Rebecca K., et al.
Publicado: (2023)

German Dentists’ Preferences for the Treatment of Apical Periodontitis: A Cross-Sectional Survey
por: Conrad, Jonas, et al.
Publicado: (2020)

The Apical Submembrane Cytoskeleton Participates in the Organization of the Apical Pole in Epithelial Cells
por: Salas, Pedro J.I., et al.
Publicado: (1997)

Relationship between the Apical Preparation Diameter and the Apical Seal: An In Vitro Study
por: Laslami, Kaoutar, et al.
Publicado: (2018)

Relation between Apical Seal and Apical Preparation Diameter: An In Vitro Study
por: Saluja, Priyanka, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_b4j4hq00bucfpj5bi0ua4pj9sv