Cargando…

TM4 of the glutamate transporter GLT-1 experiences substrate-induced motion during the transport cycle

Excitatory amino acid transporter 2 (EAAT2), also known as glial glutamate transporter type 1 (GLT-1), plays an important role in maintaining the extracellular glutamate concentrations below neurotoxic levels. The highly conserved TM2 transmembrane domain of GLT-1 maintains a stable position during...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rong, Xiuliang, Tan, Feng, Wu, Xiaojuan, Zhang, Xiuping, Lu, Lingli, Zou, Xiaoming, Qu, Shaogang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048300/ https://www.ncbi.nlm.nih.gov/pubmed/27698371 http://dx.doi.org/10.1038/srep34522

Ejemplares similares

The Accessibility in the External Part of the TM5 of the Glutamate Transporter EAAT1 Is Conformationally Sensitive during the Transport Cycle
por: Zhang, Xiuping, et al.
Publicado: (2012)

Proximity of Transmembrane Segments 5 and 8 of the Glutamate Transporter GLT-1 Inferred from Paired Cysteine Mutagenesis
por: Zhang, Xiuping, et al.
Publicado: (2011)

The archaeal glutamate transporter homologue Glt(Ph) shows heterogeneous substrate binding
por: Reddy, Krishna D., et al.
Publicado: (2022)

Transport mechanism of a glutamate transporter homologue Glt(Ph)
por: Ji, Yurui, et al.
Publicado: (2016)

Binding and transport of D-aspartate by the glutamate transporter homolog Glt(Tk)
por: Arkhipova, Valentina, et al.
Publicado: (2019)

Glutamate Transporters GltS, GltP and GltI Are Involved in Escherichia coli Tolerance In Vitro and Pathogenicity in Mouse Urinary Tract Infections
por: Niu, Hongxia, et al.
Publicado: (2023)

Structural Intermediates in a Model of the Substrate Translocation Path of the Bacterial Glutamate Transporter Homologue GltPh
por: Stolzenberg, Sebastian, et al.
Publicado: (2012)

The high‐energy transition state of the glutamate transporter homologue GltPh
por: Huysmans, Gerard H M, et al.
Publicado: (2020)

Critical amino acids in the TM2 of EAAT2 are essential for membrane‐bound localization, substrate binding, transporter function and anion currents
por: Mai, Dongmei, et al.
Publicado: (2021)

Deciphering structural rearrangements during transport process in the bacterial transporter GltPh, homolog to mammalian glutamate transporter
por: Venkatesan, SanthoshKannan, et al.
Publicado: (2012)

Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson's disease model
por: Zhang, Yunlong, et al.
Publicado: (2017)

Impairment of Neuronal Glutamate Uptake and Modulation of the Glutamate Transporter GLT-1 Induced by Retinal Ischemia
por: Russo, Rossella, et al.
Publicado: (2013)

Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies
por: Garcia-Esparcia, Paula, et al.
Publicado: (2018)

Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus
por: Rimmele, Theresa S., et al.
Publicado: (2021)

Position of the Third Na(+) Site in the Aspartate Transporter Glt(Ph) and the Human Glutamate Transporter, EAAT1
por: Bastug, Turgut, et al.
Publicado: (2012)

Involvement of the glutamate/glutamine cycle and glutamate transporter GLT-1 in antidepressant-like effects of Xiao Yao san on chronically stressed mice
por: Ding, Xiu-Fang, et al.
Publicado: (2017)

Characterization of the Visceral Antinociceptive Effect of Glial Glutamate Transporter GLT-1 Upregulation by Ceftriaxone
por: Roman, K., et al.
Publicado: (2012)

The role of hippocampal glial glutamate transporter (GLT‐1) in morphine‐induced behavioral responses
por: Saeedi, Negin, et al.
Publicado: (2021)

Retraction Note: Involvement of the glutamate/glutamine cycle and glutamate transporter GLT-1 in antidepressant-like effects of Xiao Yao san on chronically stressed mice
por: Ding, Xiu-Fang, et al.
Publicado: (2023)

Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue Glt(Tk)
por: Guskov, Albert, et al.
Publicado: (2016)

Activation of Glutamate Transporter-1 (GLT-1) Confers Sex-Dependent Neuroprotection in Brain Ischemia
por: Tejeda-Bayron, Flavia A., et al.
Publicado: (2021)

The Conformationally Sensitive Spatial Distance Between the TM3-4 Loop and Transmembrane Segment 7 in the Glutamate Transporter Revealed by Paired-Cysteine Mutagenesis
por: Qu, Qi, et al.
Publicado: (2021)

Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson's disease
por: Zhang, Yunlong, et al.
Publicado: (2017)

GLT-1 Transport Stoichiometry Is Constant at Low and High Glutamate Concentrations when Chloride Is Substituted by Gluconate
por: Kabakov, Anatoli Y., et al.
Publicado: (2015)

Astrocytic Glutamate Transporter 1 (GLT1) Deficiency Reduces Anxiety- and Depression-Like Behaviors in Mice
por: Jia, Yun-Fang, et al.
Publicado: (2020)

Distinct roles of the Na(+) binding sites in the allosteric coupling mechanism of the glutamate transporter homolog, Glt(Ph)
por: Riederer, Erika A., et al.
Publicado: (2022)

Mutation in glutamate transporter homologue GltTk provides insights into pathologic mechanism of episodic ataxia 6
por: Colucci, Emanuela, et al.
Publicado: (2023)

Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site
por: Venkatesan, SanthoshKannan, et al.
Publicado: (2015)

Downregulation of the Glial GLT1 Glutamate Transporter and Purkinje Cell Dysfunction in a Mouse Model of Myotonic Dystrophy
por: Sicot, Géraldine, et al.
Publicado: (2017)

Plasticity in expression of the glutamate transporters GLT-1 and GLAST in spinal dorsal horn glial cells following partial sciatic nerve ligation
por: Xin, Wen-Jun, et al.
Publicado: (2009)

Pre-Ischemic Treadmill Training for Prevention of Ischemic Brain Injury via Regulation of Glutamate and Its Transporter GLT-1
por: Yang, Xiaojiao, et al.
Publicado: (2012)

Neuronal activity mediated regulation of glutamate transporter GLT‐1 surface diffusion in rat astrocytes in dissociated and slice cultures
por: Al Awabdh, Sana, et al.
Publicado: (2016)

Yokukansan, a Traditional Japanese Medicine, Enhances the Glutamate Transporter GLT-1 Function in Cultured Rat Cortical Astrocytes
por: Ueki, Toshiyuki, et al.
Publicado: (2018)

PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer’s disease
por: Perrin, Florian, et al.
Publicado: (2023)

The Effect of GLT-1 Upregulation on Extracellular Glutamate Dynamics
por: Wilkie, Crystal M., et al.
Publicado: (2021)

Targeted Over-Expression of Glutamate Transporter 1 (GLT-1) Reduces Ischemic Brain Injury in a Rat Model of Stroke
por: Harvey, Brandon K., et al.
Publicado: (2011)

Kinetic mechanism of Na(+)-coupled aspartate transport catalyzed by Glt(Tk)
por: Trinco, Gianluca, et al.
Publicado: (2021)

Saturation transfer difference NMR on the integral trimeric membrane transport protein GltPh determines cooperative substrate binding
por: Hall, Jenny L., et al.
Publicado: (2020)

Gene transfer of GLT-1, a glial glutamate transporter, into the spinal cord by recombinant adenovirus attenuates inflammatory and neuropathic pain in rats
por: Maeda, Sanae, et al.
Publicado: (2008)

Glutamate Transporter GLT-1 Upregulation Attenuates Visceral Nociception and Hyperalgesia via Spinal Mechanisms Not Related to Anti-Inflammatory or Probiotic Effects
por: Lin, Y., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_d6uuspp1bpllg0c11ssa2np9gn