Another step toward DNA selective targeting: Ni(II) and Cu(II) complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes

DNA G-rich sequences are able to form four-stranded structures organized in stacked guanine tetrads. These structures, called G-quadruplexes, were found to have an important role in the regulation of oncogenes expression and became, for such a reason, appealing targets for anticancer drugs. Aiming a...

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Detalles Bibliográficos
Autores principales: Terenzi, Alessio, Lötsch, Daniela, van Schoonhoven, Sushilla, Roller, Alexander, Kowol, Christian R., Berger, Walter, Keppler, Bernhard K., Barone, Giampaolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048337/
https://www.ncbi.nlm.nih.gov/pubmed/27054617
http://dx.doi.org/10.1039/c6dt00648e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048337/
https://www.ncbi.nlm.nih.gov/pubmed/27054617
http://dx.doi.org/10.1039/c6dt00648e

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