α CAR IGF‐1 vector targeting of motor neurons ameliorates disease progression in ALS mice

OBJECTIVE: We have previously described the generation of coxsackievirus and adenovirus receptor (α CAR)‐targeted vector, and shown that intramuscular delivery in mouse leg muscles resulted in specific retrograde transduction of lumbar‐motor neurons (MNs). Here, we utilized the α CAR‐targeted vector...

Descripción completa

Detalles Bibliográficos
Autores principales: Eleftheriadou, Ioanna, Manolaras, Ioannis, Irvine, Elaine E., Dieringer, Michael, Trabalza, Antonio, Mazarakis, Nicholas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048386/
https://www.ncbi.nlm.nih.gov/pubmed/27752511
http://dx.doi.org/10.1002/acn3.335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048386/
https://www.ncbi.nlm.nih.gov/pubmed/27752511
http://dx.doi.org/10.1002/acn3.335

Ejemplares similares