A20 suppresses canonical Smad-dependent fibroblast activation: novel function for an endogenous inflammatory modulator

BACKGROUND: The ubiquitin-editing cytosolic enzyme A20, the major negative regulator of toll-like receptor (TLR)-mediated cellular inflammatory responses, has tight genetic linkage with systemic sclerosis (SSc). Because recent studies implicate endogenous ligand-driven TLR signaling in SSc pathogene...

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Detalles Bibliográficos
Autores principales: Bhattacharyya, Swati, Wang, Wenxia, Graham, Lauren Van Duyn, Varga, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048449/
https://www.ncbi.nlm.nih.gov/pubmed/27716397
http://dx.doi.org/10.1186/s13075-016-1118-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048449/
https://www.ncbi.nlm.nih.gov/pubmed/27716397
http://dx.doi.org/10.1186/s13075-016-1118-7

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