Validated determination method of tramadol and its desmethylates in human plasma using an isocratic LC-MS/MS and its clinical application to patients with cancer pain or non-cancer pain

BACKGROUND: This study aimed to develop a simultaneous determination method for tramadol and its desmethylates in human plasma using isocratic liquid chromatography coupled to tandem mass spectrometry and to validate it for pharmacokinetic evaluation in patients with cancer pain or non-cancer pain....

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Detalles Bibliográficos
Autores principales: Tanaka, Hironari, Naito, Takafumi, Mino, Yasuaki, Kawakami, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048606/
https://www.ncbi.nlm.nih.gov/pubmed/27729987
http://dx.doi.org/10.1186/s40780-016-0059-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048606/
https://www.ncbi.nlm.nih.gov/pubmed/27729987
http://dx.doi.org/10.1186/s40780-016-0059-2

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