Patient survival and tumor characteristics associated with CHEK2:p.I157T – findings from the Breast Cancer Association Consortium

BACKGROUND: P.I157T is a CHEK2 missense mutation associated with a modest increase in breast cancer risk. Previously, another CHEK2 mutation, the protein truncating c.1100delC has been associated with poor prognosis of breast cancer patients. Here, we have investigated patient survival and character...

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Detalles Bibliográficos
Autores principales: Muranen, Taru A., Blomqvist, Carl, Dörk, Thilo, Jakubowska, Anna, Heikkilä, Päivi, Fagerholm, Rainer, Greco, Dario, Aittomäki, Kristiina, Bojesen, Stig E., Shah, Mitul, Dunning, Alison M., Rhenius, Valerie, Hall, Per, Czene, Kamila, Brand, Judith S., Darabi, Hatef, Chang-Claude, Jenny, Rudolph, Anja, Nordestgaard, Børge G., Couch, Fergus J., Hart, Steven N., Figueroa, Jonine, García-Closas, Montserrat, Fasching, Peter A., Beckmann, Matthias W., Li, Jingmei, Liu, Jianjun, Andrulis, Irene L., Winqvist, Robert, Pylkäs, Katri, Mannermaa, Arto, Kataja, Vesa, Lindblom, Annika, Margolin, Sara, Lubinski, Jan, Dubrowinskaja, Natalia, Bolla, Manjeet K., Dennis, Joe, Michailidou, Kyriaki, Wang, Qin, Easton, Douglas F., Pharoah, Paul D. P., Schmidt, Marjanka K., Nevanlinna, Heli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048645/
https://www.ncbi.nlm.nih.gov/pubmed/27716369
http://dx.doi.org/10.1186/s13058-016-0758-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048645/
https://www.ncbi.nlm.nih.gov/pubmed/27716369
http://dx.doi.org/10.1186/s13058-016-0758-5

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