The BRAF(V600E) inhibitor, PLX4032, increases type I collagen synthesis in melanoma cells

Vertical growth phase (VGP) melanoma is frequently metastatic, a process mediated by changes in gene expression, which are directed by signal transduction pathways in the tumor cells. A prominent signaling pathway is the Ras-Raf-Mek-Erk MAPK pathway, which increases expression of genes that promote...

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Detalles Bibliográficos
Autores principales: Jenkins, Molly H., Croteau, Walburga, Mullins, David W., Brinckerhoff, Constance E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048745/
https://www.ncbi.nlm.nih.gov/pubmed/25989506
http://dx.doi.org/10.1016/j.matbio.2015.05.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048745/
https://www.ncbi.nlm.nih.gov/pubmed/25989506
http://dx.doi.org/10.1016/j.matbio.2015.05.007

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