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The BRAF(V600E) inhibitor, PLX4032, increases type I collagen synthesis in melanoma cells
Vertical growth phase (VGP) melanoma is frequently metastatic, a process mediated by changes in gene expression, which are directed by signal transduction pathways in the tumor cells. A prominent signaling pathway is the Ras-Raf-Mek-Erk MAPK pathway, which increases expression of genes that promote...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048745/ https://www.ncbi.nlm.nih.gov/pubmed/25989506 http://dx.doi.org/10.1016/j.matbio.2015.05.007 |