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Whole Genome Sequence Analysis of a Large Isoniazid-Resistant Tuberculosis Outbreak in London: A Retrospective Observational Study

BACKGROUND: A large isoniazid-resistant tuberculosis outbreak centred on London, United Kingdom, has been ongoing since 1995. The aim of this study was to investigate the power and value of whole genome sequencing (WGS) to resolve the transmission network compared to current molecular strain typing...

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Detalles Bibliográficos
Autores principales: Casali, Nicola, Broda, Agnieszka, Harris, Simon R., Parkhill, Julian, Brown, Timothy, Drobniewski, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049847/
https://www.ncbi.nlm.nih.gov/pubmed/27701423
http://dx.doi.org/10.1371/journal.pmed.1002137