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Sequence amplification via cell passaging creates spurious signals of positive adaptation in influenza virus H3N2 hemagglutinin
Clinical influenza A virus isolates are frequently not sequenced directly. Instead, a majority of these isolates (∼70% in 2015) are first subjected to passaging for amplification, most commonly in non-human cell culture. Here, we find that this passaging leaves distinct signals of adaptation, which...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049878/ https://www.ncbi.nlm.nih.gov/pubmed/27713835 http://dx.doi.org/10.1093/ve/vew026 |