Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

Recent studies suggest that cells make stochastic choices with respect to differentiation or division. However, the molecular mechanism underlying such stochasticity is unknown. We previously proposed that the timing of vertebrate neuronal differentiation is regulated by molecular oscillations of a...

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Detalles Bibliográficos
Autores principales: Phillips, Nick E, Manning, Cerys S, Pettini, Tom, Biga, Veronica, Marinopoulou, Elli, Stanley, Peter, Boyd, James, Bagnall, James, Paszek, Pawel, Spiller, David G, White, Michael RH, Goodfellow, Marc, Galla, Tobias, Rattray, Magnus, Papalopulu, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050025/
https://www.ncbi.nlm.nih.gov/pubmed/27700985
http://dx.doi.org/10.7554/eLife.16118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050025/
https://www.ncbi.nlm.nih.gov/pubmed/27700985
http://dx.doi.org/10.7554/eLife.16118

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