LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa

Chronic Pseudomonas aeruginosa infections cause significant morbidity in patients with cystic fibrosis (CF). Over years to decades, P. aeruginosa adapts genetically as it establishes chronic lung infections. Nonsynonymous mutations in lasR, the quorum-sensing (QS) master regulator, are common in CF....

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Detalles Bibliográficos
Autores principales: Feltner, John B., Wolter, Daniel J., Pope, Christopher E., Groleau, Marie-Christine, Smalley, Nicole E., Greenberg, E. Peter, Mayer-Hamblett, Nicole, Burns, Jane, Déziel, Eric, Hoffman, Lucas R., Dandekar, Ajai A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050340/
https://www.ncbi.nlm.nih.gov/pubmed/27703072
http://dx.doi.org/10.1128/mBio.01513-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050340/
https://www.ncbi.nlm.nih.gov/pubmed/27703072
http://dx.doi.org/10.1128/mBio.01513-16

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