Cargando…

Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABA(A) Receptors by Propofol

ABSTRACT: BACKGROUND: Propofol is a sedative agent that at clinical concentrations acts by allosterically activating or potentiating the γ-aminobutyric acid type A (GABA(A)) receptor. Mutational, modeling, and photolabeling studies with propofol and its analogues have identified potential interactio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eaton, Megan M., Germann, Allison L., Arora, Ruby, Cao, Lily Q., Gao, Xiaoyi, Shin, Daniel J., Wu, Albert, Chiara, David C., Cohen, Jonathan B., Steinbach, Joe Henry, Evers, Alex S., Akk, Gustav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050400/ https://www.ncbi.nlm.nih.gov/pubmed/26830963 http://dx.doi.org/10.2174/1570159X14666160202121319

Ejemplares similares

Perspective on the Relationship between GABA(A) Receptor Activity and the Apparent Potency of an Inhibitor
por: Germann, Allison L., et al.
Publicado: (2022)

Application of the Co-Agonist Concerted Transition Model to Analysis of GABA(A) Receptor Properties
por: Germann, Allison L., et al.
Publicado: (2019)

Kinetic and Structural Determinants for GABA-A Receptor Potentiation by Neuroactive Steroids
por: Akk, Gustav, et al.
Publicado: (2010)

Steady‐state activation and modulation of the synaptic‐type α1β2γ2L GABA(A) receptor by combinations of physiological and clinical ligands
por: Germann, Allison L., et al.
Publicado: (2019)

Activation of the α1β2γ2L GABA(A) Receptor by Physiological Agonists
por: Pierce, Spencer R., et al.
Publicado: (2021)

Activation of the Rat α1β2ε GABA(A) Receptor by Orthosteric and Allosteric Agonists
por: Germann, Allison L., et al.
Publicado: (2022)

Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam
por: Cao, Lily Q., et al.
Publicado: (2018)

Steady-state activation of the high-affinity isoform of the α4β2δ GABA(A) receptor
por: Pierce, Spencer R., et al.
Publicado: (2019)

The Mechanism of Enantioselective Neurosteroid Actions on GABA(A) Receptors
por: Tateiwa, Hiroki, et al.
Publicado: (2023)

Energetic Contributions to Channel Gating of Residues in the Muscle Nicotinic Receptor β1 Subunit
por: Akk, Gustav, et al.
Publicado: (2013)

EDITORIAL: Molecular Pharmacology of the GABA(A) Receptor
por: AKK, GUSTAV
Publicado: (2010)

Neurosteroid Modulation of GABA(A) Receptor Function by Independent Action at Multiple Specific Binding Sites
por: Wang, Lei, et al.
Publicado: (2022)

Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABA(A) Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor
por: Pierce, Spencer R., et al.
Publicado: (2023)

Site-specific effects of neurosteroids on GABA(A) receptor activation and desensitization
por: Sugasawa, Yusuke, et al.
Publicado: (2020)

Introduced Amino Terminal Epitopes Can Reduce Surface Expression of Neuronal Nicotinic Receptors
por: Bracamontes, John R., et al.
Publicado: (2016)

Multiple functional neurosteroid binding sites on GABA(A) receptors
por: Chen, Zi-Wei, et al.
Publicado: (2019)

UNC-49 is a redox-sensitive GABA(A) receptor that regulates the mitochondrial unfolded protein response cell nonautonomously
por: Pohl, Franziska, et al.
Publicado: (2023)

Fospropofol: Is there an infusion regimen for propofol equivalence?
por: Atlas, Glen
Publicado: (2011)

A propofol binding site on mammalian GABA(A) receptors identified by photolabeling
por: Yip, Grace M S, et al.
Publicado: (2013)

Meet Our Editorial Board Member
por: Akk, Gustav
Publicado: (2015)

Meet Our Editorial Board Member
por: Akk, Gustav
Publicado: (2021)

Meet the Editorial Board Member
por: Akk, Gustav
Publicado: (2022)

Outcomes of colonoscopy with non-anesthesiologist-administered propofol (NAAP): an equivalence trial
por: Alburquerque, Marco, et al.
Publicado: (2021)

A comparison of GABA-ergic (propofol) and non-GABA-ergic (dexmedetomidine) sedation on visual and motor cortical oscillations, using magnetoencephalography
por: Saxena, Neeraj, et al.
Publicado: (2021)

Pharmacological and Biophysical Characteristics of Picrotoxin-Resistant, δSubunit-Containing GABA(A) Receptors
por: Shu, Hong-Jin, et al.
Publicado: (2021)

VTA GABA Neurons at the Interface of Stress and Reward
por: Bouarab, Chloé, et al.
Publicado: (2019)

Desensitization of Mouse Nicotinic Acetylcholine Receptor Channels : A Two-Gate Mechanism
por: Auerbach, Anthony, et al.
Publicado: (1998)

Ms. Rabia Moin: A Linchpin in the Road to Success of Current Neuropharmacology
por: Nicoletti, Ferdinando, et al.
Publicado: (2022)

ROBUST PHOTO-REGULATION OF GABA(A) RECEPTORS BY ALLOSTERIC MODULATION WITH A PROPOFOL ANALOG
por: Yue, Lan, et al.
Publicado: (2012)

Contribution of the α5 GABA(A) receptor to the discriminative stimulus effects of propofol in rat
por: Wang, Benfu, et al.
Publicado: (2018)

Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats
por: Xing, Yunlong, et al.
Publicado: (2020)

Retracted: Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats
por: Neurology, Behavioural
Publicado: (2022)

Propofol Affects Cortico-Hippocampal Interactions via β3 Subunit-Containing GABA(A) Receptors
por: Kreuzer, Matthias, et al.
Publicado: (2020)

Molecular and Regulatory Mechanisms of Desensitization and Resensitization of GABA(A) Receptors with a Special Reference to Propofol/Barbiturate
por: Kang, Youngnam, et al.
Publicado: (2020)

Nicotine Dependence is Associated with Functional Variation in FMO3, an Enzyme that Metabolizes Nicotine in the Brain
por: Teitelbaum, Aaron M., et al.
Publicado: (2017)

GABA(A) Receptor in the Thalamic Specific Relay System Contributes to the Propofol-Induced Somatosensory Cortical Suppression in Rat
por: Zhang, Yu, et al.
Publicado: (2013)

Feasibility of Equivalent Dipole Models for Electroencephalogram-Based Brain Computer Interfaces
por: Schimpf, Paul H.
Publicado: (2017)

Modal Analysis of Bolted Structure Based on Equivalent Material of Joint Interface
por: Zhang, Kai, et al.
Publicado: (2019)

Randomized Double-Blind Comparison of Ketamine-Propofol and Fentanyl-Propofol for the Insertion of Laryngeal Mask Airway in Children
por: Singh, Ranju, et al.
Publicado: (2011)

Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A )receptor chloride channels
por: Ying, Shui-Wang, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_a3glupo572u03mhh3ks7v46h7q