Effects of Resistance-Associated NS5A Mutations in Hepatitis C Virus on Viral Production and Susceptibility to Antiviral Reagents

Direct-acting antivirals (DAAs) for hepatitis C virus (HCV) have potent anti-HCV effects but may provoke resistance-associated variants (RAVs). In this study, we assessed the characteristics of these RAVs and explored efficacious anti-HCV reagents using recombinant HCV with NS5A from a genotype 1b s...

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Detalles Bibliográficos
Autores principales: Nitta, Sayuri, Asahina, Yasuhiro, Matsuda, Mami, Yamada, Norie, Sugiyama, Ryuichi, Masaki, Takahiro, Suzuki, Ryosuke, Kato, Nobuyuki, Watanabe, Mamoru, Wakita, Takaji, Kato, Takanobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050404/
https://www.ncbi.nlm.nih.gov/pubmed/27703205
http://dx.doi.org/10.1038/srep34652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050404/
https://www.ncbi.nlm.nih.gov/pubmed/27703205
http://dx.doi.org/10.1038/srep34652

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