Cargando…

Effects of Resistance-Associated NS5A Mutations in Hepatitis C Virus on Viral Production and Susceptibility to Antiviral Reagents

Direct-acting antivirals (DAAs) for hepatitis C virus (HCV) have potent anti-HCV effects but may provoke resistance-associated variants (RAVs). In this study, we assessed the characteristics of these RAVs and explored efficacious anti-HCV reagents using recombinant HCV with NS5A from a genotype 1b s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nitta, Sayuri, Asahina, Yasuhiro, Matsuda, Mami, Yamada, Norie, Sugiyama, Ryuichi, Masaki, Takahiro, Suzuki, Ryosuke, Kato, Nobuyuki, Watanabe, Mamoru, Wakita, Takaji, Kato, Takanobu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050404/ https://www.ncbi.nlm.nih.gov/pubmed/27703205 http://dx.doi.org/10.1038/srep34652

Ejemplares similares

Interferon sensitivity-determining region of hepatitis C virus influences virus production and interferon signaling
por: Sugiyama, Ryuichi, et al.
Publicado: (2017)

Corrigendum: Amino Acid Polymorphisms in Hepatitis C Virus Core Affect Infectious Virus Production and Major Histocompatibility Complex Class I Molecule Expression
por: Tasaka-Fujita, Megumi, et al.
Publicado: (2015)

Amino Acid Polymorphisms in Hepatitis C Virus Core Affect Infectious Virus Production and Major Histocompatibility Complex Class I Molecule Expression
por: Tasaka-Fujita, Megumi, et al.
Publicado: (2015)

Resistance mutations of hepatitis B virus in entecavir‐refractory patients
por: Yamada, Norie, et al.
Publicado: (2017)

Hepatitis B Virus Genotype-Dependent Vulnerability of Infected Cells to Immune Reaction in the Early Phase of Infection
por: Shiina, Masaaki, et al.
Publicado: (2019)

Signal Peptidase Complex Subunit 1 Participates in the Assembly of Hepatitis C Virus through an Interaction with E2 and NS2
por: Suzuki, Ryosuke, et al.
Publicado: (2013)

Completion of the Entire Hepatitis C Virus Life Cycle in Vero Cells Derived from Monkey Kidney
por: Murayama, Asako, et al.
Publicado: (2016)

Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients
por: Nitta, Sayuri, et al.
Publicado: (2019)

Single Strain Isolation Method for Cell Culture-Adapted Hepatitis C Virus by End-Point Dilution and Infection
por: Sugiyama, Nao, et al.
Publicado: (2014)

A Subclone of HuH-7 with Enhanced Intracellular Hepatitis C Virus Production and Evasion of Virus Related-Cell Cycle Arrest
por: Murayama, Asako, et al.
Publicado: (2012)

High-throughput neutralization assay for multiple flaviviruses based on single-round infectious particles using dengue virus type 1 reporter replicon
por: Matsuda, Mami, et al.
Publicado: (2018)

Identification of neutralizing epitopes in the preS2 domain of the hepatitis B virus
por: Yato, Keigo, et al.
Publicado: (2022)

Involvement of the 3’ Untranslated Region in Encapsidation of the Hepatitis C Virus
por: Shi, Guoli, et al.
Publicado: (2016)

Antiviral Activity of Glycyrrhizin against Hepatitis C Virus In Vitro
por: Matsumoto, Yoshihiro, et al.
Publicado: (2013)

Bivalent vaccine platform based on Japanese encephalitis virus (JEV) elicits neutralizing antibodies against JEV and hepatitis C virus
por: Saga, Ryohei, et al.
Publicado: (2016)

miR-122 Stimulates Hepatitis C Virus RNA Synthesis by Altering the Balance of Viral RNAs Engaged in Replication versus Translation
por: Masaki, Takahiro, et al.
Publicado: (2015)

ULBP1 is induced by hepatitis C virus infection and is the target of the NK cell‐mediated innate immune response in human hepatocytes
por: Dansako, Hiromichi, et al.
Publicado: (2018)

Chronic Hepatitis E Infection in a Persistently Immunosuppressed Patient Unable to Be Eliminated after Ribavirin Therapy
por: Miyoshi, Masato, et al.
Publicado: (2016)

The ESCRT System Is Required for Hepatitis C Virus Production
por: Ariumi, Yasuo, et al.
Publicado: (2011)

Development and Use of a Kinetical and Real-Time Monitoring System to Analyze the Replication of Hepatitis C Virus
por: Li, Xiaoyu, et al.
Publicado: (2022)

Molecular dissection of HBV evasion from restriction factor tetherin: A new perspective for antiviral cell therapy
por: Miyakawa, Kei, et al.
Publicado: (2015)

Amino Acid Polymorphism in Hepatitis B Virus Associated With Functional Cure
por: Honda, Takashi, et al.
Publicado: (2021)

Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus
por: Kaneko, Shun, et al.
Publicado: (2016)

Raloxifene inhibits hepatitis C virus infection and replication
por: Takeda, Midori, et al.
Publicado: (2012)

Epigenetic reprogramming promotes the antiviral action of IFNα in HBV-infected cells
por: Gailhouste, Luc, et al.
Publicado: (2021)

Potent triazine-based dehydrocondensing reagents substituted by an amido group
por: Kunishima, Munetaka, et al.
Publicado: (2016)

RNA Polymerase Activity and Specific RNA Structure Are Required for Efficient HCV Replication in Cultured Cells
por: Murayama, Asako, et al.
Publicado: (2010)

A case of neonatal cytomegalovirus infection with severe thrombocytopenia that was successfully managed with empiric antiviral therapy
por: Fujimori, Kentaro, et al.
Publicado: (2019)

Modulation of host metabolism as a target of new antivirals()
por: Ikeda, Masanori, et al.
Publicado: (2007)

Performance Evaluation of In Vitro Screening and Diagnostic Kits for Hepatitis C Virus Infection
por: Murayama, Asako, et al.
Publicado: (2022)

Direct Binding of Ledipasvir to HCV NS5A: Mechanism of Resistance to an HCV Antiviral Agent
por: Kwon, Hyock Joo, et al.
Publicado: (2015)

Antiviral mechanism of preclinical antimalarial compounds possessing multiple antiviral activities
por: Gu, Weilin, et al.
Publicado: (2021)

Cooperation Between Japan’s NIID and China CDC in Japan’s COVID-19 Response
por: Wakita, Takaji
Publicado: (2020)

Genetic Variation of the IL-28B Promoter Affecting Gene Expression
por: Sugiyama, Masaya, et al.
Publicado: (2011)

New Preclinical Antimalarial Drugs Potently Inhibit Hepatitis C Virus Genotype 1b RNA Replication
por: Ueda, Youki, et al.
Publicado: (2013)

Correction: New Preclinical Antimalarial Drugs Potently Inhibit Hepatitis C Virus Genotype 1b RNA Replication
por: Ueda, Youki, et al.
Publicado: (2013)

Performance of NS3, NS5a AND NS5b Hepatitis C Virus (HCV) Antiviral Resistance Sequencing Assays
por: Nutt, Jamie, et al.
Publicado: (2017)

Therapeutic Potential of Antiviral Peptides against the NS2B/NS3 Protease of Zika Virus
por: Hossain, Md. Shahadat, et al.
Publicado: (2023)

The Future of HCV Therapy: NS4B as an Antiviral Target
por: Dvory-Sobol, Hadas, et al.
Publicado: (2010)

An Antiviral Peptide from Alopecosa nagpag Spider Targets NS2B–NS3 Protease of Flaviviruses
por: Ji, Mengyao, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_kvuuss8dgro1tjbifle7qr89p6