Genes implicated in thiopurine-induced toxicity: Comparing TPMT enzyme activity with clinical phenotype and exome data in a paediatric IBD cohort

The aim of our study was to assess the utility of next generation sequencing (NGS) for predicting toxicity and clinical response to thiopurine drugs in paediatric patients with inflammatory bowel disease. Exome data for 100 patients were assessed against biochemically measured TPMT enzyme activity,...

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Detalles Bibliográficos
Autores principales: Coelho, Tracy, Andreoletti, Gaia, Ashton, James J., Batra, Akshay, Afzal, Nadeem Ahmad, Gao, Yifang, Williams, Anthony P., Beattie, Robert M., Ennis, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050412/
https://www.ncbi.nlm.nih.gov/pubmed/27703193
http://dx.doi.org/10.1038/srep34658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050412/
https://www.ncbi.nlm.nih.gov/pubmed/27703193
http://dx.doi.org/10.1038/srep34658

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