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Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating

The flow of ions through membrane channels is precisely regulated by gates. The architecture and function of these elements have been studied extensively, shedding light on the mechanisms underlying gating. Recent investigations have focused on ion occupancy of the channel’s selectivity filter and i...

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Detalles Bibliográficos
Autores principales: Mukherjee, Saptarshi, Thomas, N. Lowri, Williams, Alan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050499/
https://www.ncbi.nlm.nih.gov/pubmed/27703263
http://dx.doi.org/10.1038/srep34452

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