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Rhein reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal fibrosis in mice

Renal fibrosis is the hallmark of chronic kidney diseases (CKD) and its development and progression are significantly affected by epigenetic modifications. Rhein, a plant-derived anthraquinone, displays strong anti-fibrosis properties, but its protective mode of action remains incompletely understoo...

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Detalles Bibliográficos
Autores principales: Zhang, Qin, Yin, Shasha, Liu, Lin, Liu, Zhihong, Cao, Wangsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050540/
https://www.ncbi.nlm.nih.gov/pubmed/27703201
http://dx.doi.org/10.1038/srep34597