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Rhein reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal fibrosis in mice
Renal fibrosis is the hallmark of chronic kidney diseases (CKD) and its development and progression are significantly affected by epigenetic modifications. Rhein, a plant-derived anthraquinone, displays strong anti-fibrosis properties, but its protective mode of action remains incompletely understoo...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050540/ https://www.ncbi.nlm.nih.gov/pubmed/27703201 http://dx.doi.org/10.1038/srep34597 |