VAChT overexpression increases acetylcholine at the synaptic cleft and accelerates aging of neuromuscular junctions

BACKGROUND: Cholinergic dysfunction occurs during aging and in a variety of diseases, including amyotrophic lateral sclerosis (ALS). However, it remains unknown whether changes in cholinergic transmission contributes to age- and disease-related degeneration of the motor system. Here we investigated...

Descripción completa

Detalles Bibliográficos
Autores principales: Sugita, Satoshi, Fleming, Leland L., Wood, Caleb, Vaughan, Sydney K., Gomes, Matheus P. S. M., Camargo, Wallace, Naves, Ligia A., Prado, Vania F., Prado, Marco A. M., Guatimosim, Cristina, Valdez, Gregorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050580/
https://www.ncbi.nlm.nih.gov/pubmed/27713817
http://dx.doi.org/10.1186/s13395-016-0105-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050580/
https://www.ncbi.nlm.nih.gov/pubmed/27713817
http://dx.doi.org/10.1186/s13395-016-0105-7

Ejemplares similares